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Treatment of early cholesterol in children

Treatment of early cholesterol in children

The risk of hypercholesterolemia may be well known in adults, so its diagnosis and treatment are particularly welcome and obvious in the 40s, but it is not expected that there will be children with high cholesterol in the blood, which later sets the stage for heart disease or stroke. Ischemic and even premature death. The earlier detection and treatment of this ratio was a kind of definite prevention of the body, according to the latest study on the impact of early diagnosis and treatment of cholesterol in children.

-Genetic causes

A study by scientists from the University of Amsterdam in the Netherlands, published in mid-October this year in the New England Journal of Medicine, showed that Statins could reduce the lives of statins. Long-term complications of increased cholesterol.

This family is one of the most popular drugs in the treatment of high cholesterol level in adults, because of its effectiveness in reducing the rise, especially harmful low-density LDL. It is known that the lower the volume and density of cholesterol molecules can leak from the blood through the openings on the wall of the arteries and deposited on them, which leads to later hardening and narrowing of diameter, and this can lead to a lack of blood flow through them to different parts of the body such as the brain and cause stroke or Heart and cause angina.

The study pointed out that the problem is that high cholesterol does not cause any symptoms and the diagnosis depends mainly on laboratory analysis, and often do not request these tests routinely when detected, as high cholesterol is not uncommon in children, but also It is not rare, with up to one in 250 children.

The causes of hypercholesterolemia are basically familial genetic hypercholesterolemia and begin at birth. The percentage of children diagnosed early does not exceed 10 percent and the very high numbers of cholesterol levels even in adults are genetic. An increase is considered as a result of genes if the ratio exceeds 160 milligrams-deciliter in children. A safe and healthy ratio is less than 100 mg-dl.

- Encouraging results

Researchers conducted the trial of 214 children with high cholesterol for genetic reasons in the late 1990s and a statin versus placebo trial for two years. Statin therapy was only completed for 20 years and followed up as adults in their 30s, after all, they were treated with moderate doses of the drug. As a result, low-density (harmful) fat decreased significantly, and 20 percent of patients had reduced their fat levels to safe levels (less than 100 mg-dl) and their risk of heart disease and early death was significantly reduced, and almost equal. With their natural peers, only 1 percent suffered from heart disease and complications compared with 26 percent, which is the expected proportion of children with genetic elevation.

No patients died before age 39, compared to 7 percent in the past, which is a very successful reduction in the risk of death from heart disease complications, as well as the health of the arteries. And none of the arteries have narrowed or hardened.

Although treatment for high cholesterol is an effective solution to protect against complications of atherosclerosis later, statin side effects must be taken into account, the most important of which is the increased likelihood of type 2 diabetes, which in turn increases the likelihood of heart disease, especially Children should start taking the drug from childhood and stay with it for life, which increases the period of exposure to side effects. However, according to the study, only one patient who took the drug had type 2 diabetes, a normal proportion that can occur even in healthy people.

The importance of the study is that it draws attention to the need to pay attention to the analysis of fat in children and not afraid of early start taking treatment for high rates, especially since the long follow-up for 20 years proved safety, thus encouraging many doctors to prescribe a statin for children, where the last option Always in the past. The average doses of the drug did not cause any side effects either diabetes or liver cell damage throughout the treatment and liver function can be monitored continuously every period to check on the health of the liver. Statin is eliminated through the liver, which can adversely affect it.

The researchers said it is not yet known whether it is possible to add another drug to these patients in the future or not, in the case of non-response, and also with the development of the emergence of cholesterol injections in the experiment phase.

Treatment of early cholesterol in children
Mohamed Hamed


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